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Muscle loss is one of the most common concerns raised about GLP-1 medications, and it deserves a more precise answer than it usually gets. A recently published mouse study added ketone supplementation
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Nausea affects up to 50% of patients, vomiting and diarrhea are common, and these symptoms lead to treatment discontinuation in up to 12% of patients compared to approximately 2% with placebo [135], an attrition pattern that may disproportionately exclude frail elderly participants
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